15  Aug 17

Characterization of Oral Lactobacilli as Potential Probiotics for Oral Health

Dr Sanjay Agrawal
Leading Pharmaceutical Consultant and Editor-in Chief of IJMToday

Intestinal lactobacilli have been successfully used as probiotics to treat gastrointestinal disorders. The pro-biotic properties of oral lactobacilli to combat oral diseases were evaluated in a study which was aimed to characterize oral lactobacilli for their potential properties according to the international guidelines for the evaluation of probiotics, and to select potential probiotics strain for oral health. Patients included 67 salivary and sub-gingival lactobacilli of 10 species, isolated from healthy humans. All strains were identified using amplified ribosomal DNA restriction analysis, tested for antimicrobial activity against oral pathogens, tolerance of low pH and bile content, followed by lysozyme tolerance. The antibiotic susceptibility of 22 potential pro-biotic strains was also assessed. Results showed that majority of strains suppressed the growth of Aggregatibacter actinomycete , Mcomitans, Prophyromonas gingivalis, Prevoltella intermedia, and Streptococcus mutans, but none of them inhibited Candida albicans. The lowest pH tolerated by lactobacilli following 4hr of incubation was pH 2.5, but none of the strains grew at this pH. All strains tolerated a high concentration of human bile (5% V/v).Four Lactobacillus plantarum and two Lactobacillus oris strains expressed resistance to tetracycline and doxycycline.

These results state that strains of Lactobacillus plantarum , Lactobacillus paracasei, Lactobacillus salivarius , and Lactobacillus rhamnosus expressed both high antimicrobial activity and high tolerance of environmental stress and thus concludes that oral lactobacilli can be used as potent pro- biotics for oral health.

Oral Microbiol Immunol 2008; 23 (2): BO-147.

  Dr. Anjali

05 Oct 2018
Excellent formulation unique and tasty !

  Dr Laryana

24 Sep 2017
very informative information


27 Aug 2017
Very true & Nice


18 Aug 2017
Grate Information


18 Aug 2017
Nice article


18 Aug 2017
Good artical


18 Aug 2017
Good artical


18 Aug 2017
Good artical

  Rajen Upadhyay

18 Aug 2017
Sir, best information about role of probiotics in oral health.


17 Aug 2017
Excellent Dr. Sanjay Sir

  Dr. Shanoo

17 Aug 2017
Very informative it is.

  Ms Laura

15 Aug 2017
Excellent insight information provided by Dr Sanjay


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