31  May 18

DOXYGEN TABLET


DR SANJAY AGRAWAL
LEADING PHARMACEUTICAL CONSULTANT AND EDITOR-IN CHIEF OF IJMTODAY

EACH TABLET CONTAINS:

- Doxylamine 10mg
- Pyridoxine 10mg
- Folic acid 2.5 mg

DESCRIPTION

Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine. Doxylamine competitively inhibits the histamine receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophiles and mast cells.

Pyridoxine is a vitamin acts as a coenzyme in the metabolism of protein, carbohydrate, and fat. Participates in the decarboxylation of amino acids, conversion of tryptophan to niacin or to serotonin (5-hydroxtryptamine), deamination, and transamination and transulfuration of amino acids. Also responsible for the breakdown of glycogen to glucose-1-phosphate.

Folic acid is a vitamin that is transformed to tetrahydrofolate polyglutamate in the body. In the form of a co-enzyme it is a donor for groups with a single carbon unit .The co-enzyme assists, amongst others, the purine synthesis.

INDICATIONS

The combination of pyridoxine, more commonly referred to as vitamin B6 and doxylamine, an antihistamine, is used for the management of nausea and vomiting of pregnancy. Also used for reduction in hyper emesis gravid arum.

DOSAGE & ADMINISTRATION

2 tablets on a daily basis at bedtime, if symptoms are not adequately controlled, increase dose to 4 tablets each day (1 tab in AM, 1 tab mid-afternoon, and 2 tabs at bedtime)

CONTRAINDICATIONS

DOXYGEN should not be administered in the following cases:

- DOXYGEN is not recommended in individuals having hypersensitivity from any of the ingredient.
- DOXYGEN should not be prescribed to individuals whom have angle-closure glaucoma.
- DOXYGEN is contraindicated in patients with renal hyperthyroidism and UTIs.

PRECAUTIONS

Caution should be exercised while prescribing DOXYGEN tablet to patients having asthma or other breathing problems, glaucoma , ulcer, or difficulty in urination.

Avoid alcoholic beverages or products containing alcohol while taking doxylamine and pyridoxine. Alcohol can add to the drowsiness caused by this medication.

ADVERSE EFFECTS

The most common side effect of DOXYGEN tablet is sleepiness or drowsiness, dizziness, stomach upset, diarrhea, constipation, headache ,they are transit side effects.

PREGNANCY & LACTATON

DOXYGEN tablet failed to demonstrate a risk to the fetus in the first trimester of pregnancy.

PRESENTATION

DOXYGEN tablets are available in a strip of 10’s tablets.

  Dr. Parul

26 Jun 2018
Useful Information

  Dr Rupa

23 Jun 2018
Excellent formualtion

  Dr Rupa

23 Jun 2018
Excellent formualtion


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