17  Jul 18

MI vs DCI


DR SANJAY AGRAWAL
LEADING PHARMACEUTICAL CONSULTANT AND EDITOR-IN CHIEF OF IJMTODAY

 

 

1. Inositol Balance:

Normal MI to DCI ratio threshold: 100:1 – 70:1

PCOS women ratio: 0.2:1

Reference:

Heimark D, McAllister J, Larner J. Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J 2014; 61:111-7.

2. Need of High concentration of MI in oocyte

High energy status (glucose utilization) in oocyte requiring high MI to DCI ratio.

Reference:

Larner J. D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3:47–60. doi: 10.1080/15604280212528.[PMC free article] [PubMed] [Cross Ref]

3. Oocyte quality

High MI would give good quality oocyte where as high DCI would yield low quality oocytes leading to infertility.

Reference:

Chiu TT, Rogers MS, Law EL, Briton-Jones CM, Cheung LP, Haines CJ. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod. 2002;17:1591–1596 doi:10.1093/humrep/17.6.1591. [PubMed] [Cross Ref]

  Ms. Antra

27 Jul 2018
very Nice


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