MI VS DCI
Normal MI to DCI ratio threshold: 100:1 – 70:1
PCOS women ratio: 0.2:1
Heimark D, McAllister J, Larner J. Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J 2014; 61:111-7.
Need of High concentration of MI in oocyte
High energy status (glucose utilization) in oocyte requiring high MI to DCI ratio.
Larner J. D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3:47–60. doi: 10.1080/15604280212528.[PMC free article] [PubMed] [Cross Ref]
High MI would give good quality oocyte where as high DCI would yield low quality oocytes leading to infertility.
Chiu TT, Rogers MS, Law EL, Briton-Jones CM, Cheung LP, Haines CJ. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod. 2002;17:1591–1596 doi:10.1093/humrep/17.6.1591. [PubMed] [Cross Ref]