COMPOSITON:
Each CEFIGEN-O tablet contains 200 mg of Cefixime Trihydrate IP (equivalent to N-hydroxy cefixime) and 200 mg of Ofloxacin IC.
DESCRIPTION:
Cefigen-O is a brand name for the antibiotic combination of Cefixime, the 3rd generation cephalosporin antibiotic, and Ofloxacin, a fluoroquinolone antibiotic. Cefigen-O exhibits broad-spectrum activity, with a longer half life and higher penetrability. This combination treats major bacterial infections such as ear, nose, and throat infections, upper respiratory tract infections, and genitourinary tract infections.
Cefixime is one of the very few antibiotics that are stable against cephalosporinase and beta-lactamase activity. Cefixime is a beta-lactam antibiotic that works by inhibiting the cell wall synthesis in the bacterial cells. This drug binds to specific penicillin-binding proteins (PBPs), which control the transactivation step of peptidoglycan synthesis. This binding between the PBPs and the beta-lactam ring of cefixime prevents the cell wall synthesis, eventually leading to the bacterial cell death.
Oflaxime is a synthetic antibiotic that belongs to the class of 2nd-generation fluoroquinolones. It acts on the DNA gyrase and topoisomerase IV enzymes that are associated with the DNA replication in the bacteria. By binding to these enzymes, Ofloxacin hampers the unbinding and supercoiling properties of these enzymes and eventually arrests the cell growth in bacteria.
INDICATIONS:
- Bronchitis
- Disseminated gonococcal infection
- Pelvic inflammatory diseases
- Propagatis
- Community-acquired Pneumonia
- Gonorrhea
- Lyme disease
- Otitis media
- Pharyngitis
- Tonsilitis
- Shigellosis
- Typhoid fever
- Brucellosis
- Gonococcal urethritis
- Cervicitis
- Multibacillary leprosy
- Skin/skin structure infection
- Otitis externa
- Urinary tract infection
- Bacterial sinusitis
DOSES AND ADMINISTRATION:
1 tab twice a Day or as directed by the physician
CONTRAINDICATION:
The Cefigen-O tablet is contraindicated in patients with hypersensitivity towards cefixime and ofloxacin. This medicine is also contraindicated in patients with epilepsy, clostridium difficile infection, myasthenia gravis, renal insufficiency and seizures
ADVERSE EFFECTS:
The adverse effects of this medicine include abdominal pain, nausea, vomiting, severe itching of the skin, insomnia, dizziness, emesis, dyspepsia, headache, diarrhea, eosinophilia, hallucination, and sinus tachycardia.
PRECAUTION:
There are no sufficient and well-controlled studies when it comes to Cefixime and Ofloxacin administration in pregnant women and nursing mothers; therefore, if you’re pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
PRESENTATION:
Cefigen-O tablets are available in 10×10 alu-alu packing.
WARNING:
Patients suffering from neurological complication should take the tab under medical supervision
USPs:
- Both the drugs are available in a therapeutic consultation
- Doses are convenient
- The packaging is attractive
