Brief Product Information on CEFIGEN-O
Brief Product Information on CEFIGEN-O

Dr. Sanjay Agrawal

Leading Pharmaceutical consultant and editor-in chief of IJMToday


Each CEFIGEN-O tablet contains Cefixime Trihydrate IP (equivalent to N-hydra cefixime) 200 mg and Ofloxacin IC 200 mg.   


Cefigen-O is a brand name for the anti-biotic combination of Cefixime, the 3rd generation cephalosporin anti biotics and Ofloxacin, a fluoroquinolone anti biotic. Cefigen-O exhibits broad-spectrum activity, with a longer half life and higher penetrability. This combination treats major bacterial infections such as ear, nose and throat infection, upper respiratory tract infection and genito urinary tract infection.

Cefixime is one of the very few antibiotics that are stable against cephalosporinase and beta-lactamase activity. Cefixime is a beta lactam antibiotic that works by inhibiting the cell wall synthesis in the bacterial cells. This drug binds to specific penicillin-binding protein (PBPs), which control the trans activation step of peptidoglycan synthesis. This binding between the PBPs and beta lactam ring of cefixime prevents the cell wall synthesis, eventually leading to the bacterial cell death.

Oflaxime is a synthetic antibiotic that belongs to the class of 2nd generation fluoroquinolones. It acts on the DNA gyrase and Topoisomerase IV enzymes that are associated with the DNA replication in the bacteria. By binding to these enzymes, Ofloxacin hampers the unbinding and super coiling properties of these enzymes and eventually arrest the cell growth in bacteria.


  • Bronchitis
  • Disseminated gonococcal infection
  • Pelvic inflammatory diseases
  • Propatatis
  • Community acquired Pneumonia
  • Gonorrhea
  • Lyme diseases
  • Otitis media
  • Pharyngitis
  • Tonsilitis
  • Shigellosis
  • Typhoid fever
  • Brucellosis
  • Gonococcal urethritis
  • Cervicitis
  • Multibacillary leprosy
  • Skin/ skin structure infection
  • Otitis externa
  • Urinary tract infection
  • Bacterial sinusitis


1 tab twice a Day or as directed by the physician


Cefigen-O tablet in contraindicated in patients with hyper sensitivity towards Cefixime and Ofloxacin. This medicine is also contra indicated in patients with epilepsy, clostridium difficil infection, myasthenia gravis, renal insufficiency and seizures


The adverse effects of this medicine include abdominal pain, nausea, vomiting, severe itching of the skin, insomnia, dizziness, emesis, dyspepsia, headache, diarrhea, dosinophilia, hallucination and spinus tachycardia.


There are no sufficient and well controlled studies when it comes to Cefixime and Ofloxacin administration in pregnant women and nursing mothers, therefore if u r pregnant or nursing discuss with your doctor about your condition before taking this medicine.


Cefigen-O tablets are available in 10×10 alu-alu packing.


Patients suffering from neurological complication should take the tab under medical supervision


  • Both the drugs are available in a therapeutic consultation
  • Doses are convenient
  • The packaging is attractive

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