COMPOSITION
Each 5 ml of Relivo-D syrup contains:
- Dextromethorphan – 10 mg
- Phenylephrine – 5 mg
- Chlorpheniramine Maleate (CPM) – 2 mg
DESCRIPTION
Relivo-D is a nasal decongestant and anti-histamine combination that works by blocking the brain’s cough-triggering region, inhibiting histamine’s activity during the allergic reaction, and, lastly, causing the blood vessels to constrict to relieve nasal congestion.
Dextromethorphan acts centrally and raises the threshold for coughing without interfering with the ciliary action. This drug is strictly absorbed in the GI tract and converted to the activated metabolite in the liver. Dextromethorphan enters the bloodstream and crosses the blood-brain barrier to exhibit its cough-suppressing activity. It suppresses the cough reflex by directly acting on the cough center in the medulla. Its mechanism of action does not involve opioid receptors.
Chlorpheniramine Maleate, or CPM, alleviates allergic conditions such as hay fever, rhinitis, urticaria, and asthma. It is one of the widely used antihistamines with lesser sedative activities. Histamines are released during the inflammatory reaction, and when these molecules react with H1 receptors, it leads to pruritus, vasodilatation, hypotension, flushing, headache, and bronchoconstriction.
Chlorpheniramine Maleate is a histamine 1 receptor antagonist belonging to the alkylamines class and binding to the H1 receptors. By binding to the histamine H1 receptor, chlorpheniramine maleate blocks the activity of the endogenous histamine. It temporarily relieves allergic reactions like sneezing, watery and itchy eyes, and running nose.
Phenylephrine is a powerful vasoconstrictor that constricts the mucosa of the respiratory tract, thereby decreasing the swelling of the blood vessels in the nose. This drug selectively acts on the alpha-1 adrenergic agonist and exerts a decongestant action in the nasal cavity.
It reduces the discomfort and eases the breathing.
INDICATIONS
- Unproductive and dry cough
- Throat irritation
- Dry and itchy feeling in the throat
- Sore throat
- Common cold
- Sneezing and allergy
DOSES AND ADMINISTRATION
1 tsp 3 times a day or as directed by the physician.
CONTRAINDICATIONS
Relivo-D is contraindicated in patients with hypersensitivity towards its ingredients. It is also contraindicated in patients with severe hypertension, hyperthyroidism, cardiac disorders, advanced hepatic diseases, and advanced respiratory disorders.
ADVERSE EFFECTS
Adverse effects of this medication are
- Skin rashes
- Drowsiness
- Headaches
- Nausea
- Vomiting
- Breathing difficulty
PRECAUTION
There are no sufficient and well-controlled studies regarding the combinational administration of dextromethorphan, phenylephrine, and CPM in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctors about your condition before taking this medicine.
USPs
- Effective combination in dry cough
- Effective in allergic disorders
- Highly delicious
WARNINGS
Patients with hypertension, cardiac, and hepatic diseases are consumed under medical supervision.
PRESENTATION
Relivo-D is available in a 100 ml PET bottle without a box.
