Brief Product Information on TRYGEN-BRD
Brief Product Information on TRYGEN-BRD

Dr. Sanjay Agrawal

Leading Pharmaceutical consultant and editor-in chief of IJMToday


Each Trygen-BRD tablet contains Trypsin 48mg, Bromelain 90mg, Rutoside Trihydrate 100mg, and Diclofenac Potassium 50mg.


Trygen-BRD is a unique formulation of Proteolytic enzymes and Bioflavonoids that soothes swelling, inflammation and promotes faster wound healing. This combination is studied to be a safer alternative for several non-steroidal anti-inflammatory drugs (NSAIDs) that come with many side effects.

Trypsin and Bromelain are proteolytic enzymes, whose prime function is to modulate the inflammatory processes. The mechanisms opted by these enzymes to reduce the inflammation include reduction of swelling in mucus membrane, reduction of capillary permeability and dissolution of the fibrin deposits at the area of inflammation. These enzymes also break down these cellular debris and other plasma proteins at the sight of infection and thereby promote faster healing of the wounds and infections. Proteolytic digestion of the cell debris addresses sluggish lymphatic system and eases the pain and swelling that are associated with the inflammation. Trypsin and Bromelain also protect the cells against free radical damage. Rutoside is a flavonoid derivative with a strong anti-inflammatory, anti-allergic and immune modulating activities. It blocks the platelet aggregation, reduces the capillary permeability and improves the blood circulation. A sluggish circulatory system is one of the major reasons for inflammation, as the body fails to get rid of the free radicals, toxic compounds and cell debris. Rutoside is also an antioxidant that neutralizes the activity of the free radicals at the joints, prevents collagen degeneration and heals the wounds at a faster rate.

Diclofenac Potassium is a potent NSAID with excellent analgesic properties. This drug suppresses the inflammation and its symptoms by inhibiting the leukocyte migration and the activity of the enzyme, cyclooxygenase (COX-1 and COX-2).

Cyclooxygenase or the prostaglandin synthetase is the enzyme that synthesizes prostaglandins and other inflammatory mediators from arachidonic acid. These prostaglandins are associated with pain and swelling and suppress their production, which eventually relieve the pain.



  • Osteo-arthritis
  • Rheumatoid arthritis
  • Gout
  • Joint issues related to inflammation
  • Pain and swelling of the joints
  • Swelling associated with surgical wounds
  • Pulmonary edema
  • Ulcerative colitis
  • Sports injuries
  • Muscular cramps and spasms
  • Tendinitis


One tablet twice in a day or directed by the physician


Trygen-BRD tablets are contraindicated in patients with hyper sensitivity towards the ingredients of this combination. It is also contraindicated in patients with hemophilia, liver disorders, kidney disorders and in patients undergoing hemodialysis


Adverse effects of this medicine include dark colored stools, stomach bloating, flatulence, nausea and vomiting.


There are no sufficient and well controlled studies when it comes to Trypsin, Bromelain, Rutoside trihydrate and Diclofenac Potassium administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.



Patients who are suffering from gastrointestinal disturbances like peptic ulcers, duodenal ulcers and any internal bleeding use this medicine under medical supervision only.


  • Most effective combination due to better bioavailability
  • Well accepted
  • With convenient doses


Trygen-BRD tablets is available in 10×10 alu-alu packing.

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